Aesthetic

Skin, Soft Tissues, and Hair

A single-center, dose-comparison, pilot study of botulinum neurotoxin type A in female patients with upper facial rhytids: Safety and efficacy

Carruthers A, Carruthers J (Univ of British Columbia, Vancouver) J Am Acad Dermatol 60:972-979, 2009^§

Abstract

Background

Treating multiple upper facial rhytids at one time is common, but has not been researched extensively.

Objective

We sought to compare the safety, efficacy, and effect duration of 3 botulinum neurotoxin type A (BoNTA) doses in treating multiple upper facial rhytids.

Method

Sixty women, randomized to 32, 64, or 96 U total doses, were assessed at baseline, week 2, week 4, then every 4 weeks. The primary efficacy measure was proportion of responders on the patient global assessment of improvement. Adverse events (AEs) were monitored.

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