Acquired protein C deficiency
Acquired protein S deficiency
Vitamin K antagonist, vitamin K deficiency
Vitamin K antagonist, vitamin K deficiency
Hepatic insufficiency
Hepatic insufficiency
Disseminated intravascular coagulation
Disseminated intravascular coagulation
Autoimmune syndrome
Pregnancy
L-asparaginase therapy
Autoimmune syndrome
AIDS, varicella-zoster virus
Nephrotic syndrome
23.2 Diagnosis
Medical context:
In newborn, homozygote protein C or protein S deficiency manifests in fatal purpura fulminans.
In adult with heterozygous protein C or protein S deficiency, introduction of vitamin K antagonist can induce skin necrosis within 3 to 5 days.
Semiology
A massive thrombosis of the dermic vascular network can lead to large ecchymotic patches that can evolve to hemorrhagic bullae and then irreversible necrosis.Related posts:
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