Aprepitant plus Ondansetron Compared with Ondansetron Alone in Reducing Postoperative Nausea and Vomiting in Ambulatory Patients Undergoing Plastic Surgery

Vallejo MC, Phelps AL, Ibinson JW, et al (Univ of Pittsburgh Med Ctr, PA; Univ of Pittsburgh Med Ctr Veterans Affair Med Ctr, PA; Univ of Pittsburgh Med Ctr St Margaret Hosp, PA; et al) Plast Reconstr Surg 129:519-526, 2012^§

Abstract

Background

Postoperative nausea and vomiting is a major challenge in the perioperative setting. The incidence can be as high as 80 percent, and the majority of the symptoms among outpatients occur after discharge. This study evaluated the efficacy of a neurokinin-1 receptor antagonist (aprepitant) in reducing postoperative symptoms for up to 48 hours in patients undergoing outpatient plastic surgery.

Methods

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