A 26-year-old man diagnosed with pemphigus vulgaris (PV) has been under treatment for 1.5 years. The treatment was started with 80 g/day of prednisone along with 2 g/day of mycophenolate mofetil . During this period, after reduction of prednisone, in spite of simultaneous application of mycophenolate mofetil, the disease relapsed twice: when he was on 15 mg/day of prednisone and the other time when he was on 20 mg/day of prednisone. Due to several relapses, treatment with 2 g of rituximab was started 6 months ago, which controlled the symptoms. Now he is on 15 mg/day of prednisone without adjuvant and has had no relapses in the past 6 months. The dose of prednisone is now going to be tapered.