Functional Outcome Following Nerve Repair in the Upper Extremity Using Processed Nerve Allograft

Cho MS, Rinker BD, Weber RV, et al (Antonio Military Med Ctr, Fort Sam, Houston, TX; Univ of Kentucky, Lexington; Inst for Nerve, Hand, and Reconstructive Surgery, Rutherford, NJ; et al) J Hand Surg 37A:2340-2349, 2012^§

Abstract

Purpose

Reconstruction of peripheral nerve discontinuities with processed nerve allograft has become increasingly relevant. The RANGER Study registry was initiated in 2007 to study the use of processed nerve allografts in contemporary clinical practice. We undertook this study to analyze outcomes for upper extremity nerve repairs contained in the registry database.

Methods

We identified an upper extremity-specific population within the RANGER Study registry database consisting of 71 nerves repaired with processed nerve allograft. This group was composed of 56 subjects with a mean age of 40 ± 17 years (range, 18–86 y). We analyzed data to determine the safety and efficacy of processed nerve allograft. Quantitative data were available on 51 subjects with 35 sensory, 13 mixed, and 3 motor nerves. The mean gap length was 23 ± 12 mm (range, 5–50 mm). We performed an analysis to evaluate response-to-treatment and to examine sensory and motor recovery according to the international standards for motor and sensory nerve recovery.

Results

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