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Role of tumor necrosis factor–α and matrix metalloproteinase–9 in blood-brain barrier disruption after peripheral thermal injury in rats: Laboratory investigation

Reyes R, Guo M, Swann K, et al (The Univ of Texas Health Science Ctr at San Antonio) J Neurosurg 110:1218-1226, 2009^§

R.E. Salisbury, MD

Evidence Ranking

• D

Expert Rating

• 3

Abstract

Object

A relationship has been found between peripheral thermal injury and cerebral complications leading to injury and death. In the present study, the authors examined whether tumor necrosis factor–α (TNF–α) and matrix metalloproteinase–9 (MMP-9) play a causative role in blood-brain barrier (BBB) disruption after peripheral thermal injury.