APPENDIX 3 Principles of Therapeutics for Vulvovaginal Disease
The management of women with chronic vulvovaginal symptoms requires a multifaceted approach. Generally, gynecologists are accustomed to curing their patients, and women expect their gynecologist to cure their problems. However, chronic vulvovaginal symptoms are most often produced by chronic dermatoses or pain syndromes which are not treated quickly or definitively. More often, their symptoms are controlled or improved, sometimes using more than one intervention. Some of the more common causes of management failures include unreasonable expectations, undertreatment either by potency or duration, and inattention to secondary factors.
Nonspecific measures
There are several nonspecific measures that are important in achieving the best outcome for women with chronic vulvovaginal symptoms (Table A3.1). Inattention to these can prevent the success of otherwise correct and reasonable specific management.
Patient education |
Address depression, anxiety, psychosexual dysfunction |
Decrease irritants |
Control secondary infections |
Replace estrogen when deficient |
Re-evaluate flares |
Patient education
Women with chronic vulvovaginal symptoms require education regarding the nature of their condition, therapy, expectations as to rapidity of improvement, and expectations as to duration of therapy required. Patients should be taught about their disease, causes, and the options for therapy. Most often, the conditions producing chronic vulvovaginal symptoms are unfamiliar to patients, so that written information can be crucial to understanding and successful management. Patient handouts on the more common diseases are found in Appendix 4. Part of patient education is reassurance regarding sexual transmission, infertility, risk of malignancy, absence of human immunodeficiency virus (HIV), or other dangerous accompanying diseases.
Avoidance of irritants
The local environment of anogenital skin produces unique issues. Chronic symptoms are usually multifactorial. Prolonged moisture from sweat, urine, and normal and abnormal vaginal secretions, friction of skin folds, and heat combine to increase the risk of intermittent trivial but annoying infections, heavy colonization of normal organisms, and irritant contact dermatitis. The clinician should evaluate for any contributing factors both on the vulva and within the vagina. Specifically, irritant contact dermatitis from overwashing, an atrophic vagina from estrogen deficiency, and secondary infections should be evaluated for and addressed. A handout which specifically lists irritating activities to avoid can be extremely useful for patients who may find a drastic change in habits psychologically difficult (Table A3.2). Many women have focused on their vulvovaginal symptoms, arranging their lives, activities, diet, and choice of clothing all in the context of their genital symptoms. Therefore, minimizing daily care often helps to relieve anxiety as well. For a woman with isolated vulvovaginal symptoms, the choice of detergent and fabric softener is unimportant. Double-rinsing underwear serves no purpose. The color and the fabric of panties are unimportant unless the patient finds that particular types of underwear are uncomfortable. Low-yeast diets, avoidance of sugar, and eating or douching with yogurt or lactobacilli provide no substantiated benefits.
Too frequent washing |
Soaps |
Panty liners |
Topical medications |
Hair dryers |
Fingernails |
Personal lubricants (KY) |
Not only do overuse of medications and hygiene measures by patients worsen symptoms, but clinician-prescribed therapies frequently cause or exacerbate symptoms. For example, antibiotics or corticosteroids can precipitate yeast, and creams contain alcohols and preservatives that can sting with application and produce an irritant dermatitis. Therefore, ointments are generally preferred over creams. When reasonable, oral therapy is favored over topical medication in order to avoid these problems. Patients who require vaginal corticosteroids, vaginal estrogen, or antibiotics, and particularly those who receive a combination of these agents, are at a high risk for secondary candidiasis. These patients benefit from initial preventive medication, most often in the form of weekly fluconazole 150 mg.
First aid for acute symptoms and flares
Patients with severe itching or burning due to inflammation, redness, erosion, ulceration, excoriation, or infection often need immediate first aid for comfort while awaiting effects of specific therapy (Table A3.3). In addition to reassurance and patient education, there are nonspecific measures that can improve symptoms in the short term.
Soaks |
Emollients |
Ice |
Topical anesthetics |
Nighttime sedation |
Following soaks, the skin should be patted dry gently, and the moisture sealed in immediately with the application of a bland emollient such as petrolatum (Vaseline petroleum jelly). Although historically avoided by gynecologists, there are several studies that incidentally exhibit the benefit of petrolatum on pain and irritation in the course of evaluating the effects of testosterone1. Petrolatum is a cost-effective emollient that contains no irritants, allergens, preservatives, or stabilizers. Women who are incontinent or have diarrhea often benefit from a barrier paste that protects surrounding skin. Although messy, zinc oxide paste or Desitin applied liberally and regularly protects the skin from alkaline urine and, especially, liquid feces.