Breast

Cancer and Reconstruction

Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers With Cancer Risk and Mortality

Domchek SM, Friebel TM, Singer CF, et al (Univ of Pennsylvania School of Medicine, Philadelphia; Med Univ of Vienna, Austria; et al) JAMA 304:967-975, 2010^§

Abstract

Context

Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 or BRCA2 mutations to reduce their risks of breast and ovarian cancer.

Objective

To estimate risk and mortality reduction stratified by mutation and prior cancer status.

Design, Setting, and Participants

Prospective, multicenter cohort study of 2482 women with BRCA1 or BRCA2

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