Five months after the diagnosis and 4 weeks after the last chemotherapy cycle, we performed an oncologic resection of the tumor including the NAC using an inverse-T reduction mammoplasty. The preoperative drawings are seen in Fig. 65.1; the postoperative picture is illustrated in Fig. 65.2. Final histology demonstrated ympT2 ypN2a (5/16) G2 invasive ductal adenocarcinoma of the right breast resected with clear margins R0. In total we resected about 400 cm³ of breast tissue. The patient received perioperative antibiotic prophylaxis, and a frozen section was done to demonstrate clear margins during surgery. We had to do one re-resection positive margins during surgery and resection of the NAC. The patient received adjuvant endocrine treatment with tamoxifen and goserelin as well as local radiotherapy to the supraclavicular nodes and the breast including a boost.