Lisch nodules are pigmented, melanocytic, iris hamartomas. They increase in number with age and are asymptomatic. Slit-lamp examination is essential for differentiations from iris freckles.

Neurofibroma tumors are usually not present in childhood, but they begin to appear at puberty. Tumors increase in both number and size as the patient ages.

Neurofibromatosis is characterized by café-au-lait macules, neurofibromas, and axillary and groin freckling. Axillary freckling is also called Crowe sign.