Large 5-cm targetoid patch with central clearing, bright-red expanding border and central bite inflammation, characteristic of the erythema migrans rash of Lyme disease.

Erythema migrans. ‘Bull’s-eye’ lesion. Bright-red or pink expanding circulate patch with central clearing. Bite mark is usually centrally located.

Multiple inflamed expanding erythematous patches, with central bluish hue characteristic of disseminated Lyme disease.

Embedded engorged tick.