Lentigines are common, benign, brown macules on the sun-exposed skin of Caucasians.

Lentigines (liver spots) occur in sun-exposed areas of the face, arms, and hands.

Labial lentigines occur on the vermillion border of the lower lip. They have a smooth border and are benign.

Reactive hyperplasia of melanocytes causes persistent pigmentation in the form of lentigines on the neck and upper back.