Peripheral Nerve Injury and Repair

An in vivo engineered nerve conduit–fabrication and experimental study in rats

Penna V, Munder B, Stark G-B, et al (Albert-Ludwigs Univ, Freiburg, Germany; Sana Clinic Gerresheim, Germany; et al) Microsurgery 31:395-400, 2011^§

Abstract

Background

Several types of nerve conduits have been used for peripheral nerve gap bridging. This study investigated the in vivo engineering of a biological nerve conduit and its suitability for nerve gap bridging.

Material and Methods

A 19-mm long polyvinyl chloride (PVC) tube was implanted parallely to the sciatic nerve. After implantation, a connective tissue cover developed around the PVC-tube, the so-called biogenic conduit. Histological cross-sections were performed after 1, 2, 3, and 4   weeks. Wall thicknesses were measured and all vessels per cross-section were counted. The biogenic conduit filled with fibrin was used to bridge a 15-mm long nerve gap in the sciatic lesion model of the rat (n = 8). The results of nerve repair with the conduit were compared to the autologous nerve graft (n

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