Hyaluronic Acid Surface Modification of Lyophilized Flexor Tendon: A Biomechanical Study in a Canine in Vitro Model

Hand: Tendon


Carbodiimide-Derivatized Hyaluronic Acid Surface Modification of Lyophilized Flexor Tendon: A Biomechanical Study in a Canine in Vitro Model


Ikeda J, Zhao C, Sun Y-L, et al (Mayo Clinic, Rochester, MN) J Bone Joint Surg Am 92:388-395, 2010§



J.B. Tang, MD



Evidence Ranking


• D



Expert Rating


• 2



Abstract



Background


Intrasynovial grafts are the ideal solution to replace defects in intrasynovial flexor tendons, but autologous graft sources are rarely available. The purpose of the present study was to test the hypotheses that an intrasynovial tendon prepared with repetitive freeze-thaw cycles and lyophilization (as a means of reducing immunogenicity) has increased frictional force (gliding resistance) in comparison with fresh intrasynovial tendons and that a lyophilized intrasynovial flexor tendon that is modified with carbodiimide-derivatized hyaluronic acid and gelatin has decreased frictional force in comparison with untreated lyophilized tendons.



Methods

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Apr 2, 2016 | Posted by in Hand surgery | Comments Off on Hyaluronic Acid Surface Modification of Lyophilized Flexor Tendon: A Biomechanical Study in a Canine in Vitro Model

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