Pemphigus was derived from the Greek word pemphix, which means vesicle or blister [1]. There are many different types of pemphigus, all involving vesicle formation at some stage, but the most common of all of them is pemphigus vulgaris. All types of pemphigus involve acantholysis , which means the breaking apart of intercellular connections through an autoantibody-mediated response. It was in 1964 that researchers first found that antibodies were responsible for breaking the intercellular connections between keratinocytes leading to this disease. Then, in 1971 through immunofluorescent staining, it was found that the body produces immunoglobulin G (IgG) autoantibodies against the intercellular substance that holds epithelial cells together.