Erythema multiforme is commonly seen on the extremities, especially palms and soles. Iris or target lesions are classically seen along with fixed urticaria-like papules.

The central portion of the target lesion can appear dark red, blister, and heal with scale crust.

Erythema multiforme shows numerous lesion morphologies, urticaria-like papules, vesicles, bullae, and target-shaped papules.