The Effect of Collagen Nerve Conduits Filled with Collagen-Glycosaminoglycan Matrix on Peripheral Motor Nerve Regeneration in a Rat Model

Lee J-Y, Giusti G, Friedrich PF, et al (The Catholic Univ of Korea, Suwon, South Korea; Mayo Clinic, Rochester, MN; et al) J Bone Joint Surg Am 94:2084-2091, 2012^§

Abstract

Background

Bioabsorbable unfilled synthetic nerve conduits have been used in the reconstruction of small segmental nerve defects with variable results, especially in motor nerves. We hypothesized that providing a synthetic mimic of the Schwann cell basal lamina in the form of a collagen-glycosaminoglycan (GAG) matrix would improve the bridging of the nerve gap and functional motor recovery.

Methods

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