(1)
Department of Dermatology, University of Pennsylvania, Penn Presbyterian Medical Center Medical Arts Building, Philadelphia, PA, USA
3.1.1 Acute
3.1.2 Subacute
3.1.3 Chronic
3.2 Types of Eczema
3.2.1 Contact Dermatitis
3.2.2 Atopic Dermatitis
3.2.3 Nummular Dermatitis
3.2.6 Infectious Eczematoid
3.2.7 Drug Dermatitis
3.2.8 Stasis Dermatitis
3.2.13 Seborrheic Dermatitis
3.2.14 Other Eczemas
Abstract
Eczematous diseases are mostly epidermal. They are defined by “spongiotic dermatitis” on pathology, and clinically they may present in one of three stages (acute, subacute, or chronic) and in different contexts (types). The word “eczema” is derived from ancient Greek, meaning “to boil,” a reflection of the acute vesicular stage. Though many physicians and lay people use the word “eczema” synonymously with “atopic dermatitis,” the word “eczema” in this book is used differently. “Eczema” (or “dermatitis”) here is defined as a spongiotic reaction pattern that may present in different locations and contexts, with different names applied. For instance, in the context of atopy, a spongiotic dermatitis could be called atopic dermatitis. Other diseases including pityriasis rosea and dermatophytosis can also cause a spongiotic dermatitis.
Keywords
Eczematous diseasesEczema3.1 The Three Stages of Eczema
3.1.1 Acute
Clinical = edematous, red, vesicular, weeping eruption
Ddx vesiculobullous disease
Path: stratum corneum = basket weave, epidermis = intraepidermal vesicles/spongiosis, dermis = mild infiltrate
3.1.2 Subacute
Clinical = red and scaly eruption, may have crusting
Ddx papulosquamous disease
Path: stratum corneum = scale/crust, epidermis = acanthosis, exocytosis, dermis = denser infiltrate
3.1.3 Chronic
Clinical = dry, lichenified eruption
Path: stratum corneum = hyper/parakeratosis, epidermis = less spongiosis/more psoriasiform, dermis = fibrosis
3.2 Types of Eczema
CANDID SCALES mnemonic1
Contact, Atopic, Nummular, Dyshidrotic, Id reaction and Infectious eczematoid, Drug, Stasis, CTCL, Asteatotic, LSC, Erythroderma, Seborrheic
Classic clues to distinguishing different eczematous disorders
Location
Legs – asteatotic eczema, stasis dermatitis
Hands/feet – dyshidrotic eczema, contact dermatitis
Ankles/neck – lichen simplex chronicus
Antecubital/popliteal fossae/face – atopic dermatitis
Pattern
Round weepy plaques – nummular eczema
Lichenified plaques – lichen simplex chronicus, atopic dermatitis
Linear or patterned mostly on hands/ft – contact dermatitis
Generalized – atopic dermatitis, cutaneous T-cell lymphoma, drug reaction
Associated Disease
Asthma/allergic rhinitis – atopic dermatitis
Venous stasis – stasis dermatitis
Wound – contact dermatitis (neomycin), infectious eczematoid
Lower extremity infection or dermatitis – id reaction
Psychiatric disorder or “neurodermatitis” – lichen simplex chronicus
3.2.1 Contact Dermatitis
(a)
Allergic contact dermatitis (ACD)
(b)
Irritant contact dermatitis (ICD)
(c)
Photoallergic contact dermatitis
(d)
Phototoxic contact dermatitis
Contact dermatitis can be divided by the type and specificity of the eruption. Irritant dermatitis causes 80 % of reactions, allergic only 20 %
3.2.1.1 Allergic Contact Dermatitis
An immunologic response in some individuals, type IV hypersensitivity reaction, 24–48 hours after contact (on re-exposure)
Clinical suspicion with patterned, linear, or geometric shapes; anatomical restriction to hands or feet, for instance. Eyelids are easily affected.
Patch testing may be indicated to detect allergen; most common test is TRUE test = Thin-layer Rapid Use Epicutaneous test
Common Contact Allergen Categories
Plants
Metals
Fragrances
Preservatives
Textiles
Personal care products
Topical medications
Plants
Four main genera of plants responsible for allergic contact dermatitis, all start with the letter A (Mnemonic AAAA):
Anacardiaceae
Alstroemeriaceae
Asteraceae
Alliaceae
Anacardiaceae (cashew and sumac family)
Toxicodendron is the poison ivy genera, formerly Rhus (reaction was called Rhus dermatitis)
Poison ivy (pointed 3 leaves)
Poison sumac (many pointed leaves)
Poison oak (rounded 3 leaves)
#1 plant cause of allergic contact dermatitis = poison ivy
Allergen = sap containing urushiol (a mixture of catechols)
Common cross reactants (all in Anacardiaceae family): cashew (Anacardium occidentale), mango rind (not fruit), gingko tree (leaf pulp, not supplement), lacquer tree of Japan, Brazilian pepper tree, Indian marking tree
Can cause erythema multiforme
Bentoquatam (IvyBlock) absorbs urushiol and can prevent eruption
Mnemonic: Anacardiaceae sounds like Ana Kardashian, the lesser known Kardashian that stings and burns
Alstroemeriaceae (Peruvian lily)
#1 cause of contact dermatitis in florists
Sensitizer = tuliposidase A
Asteraceae
Star-shaped plants (“aster” = star in Latin) = chrysanthemum (#2 cause of contact in florists), ragweed, feverfew, artichoke
Sensitizer = sesquiterpene lactones (SQLs)
Permethrin is made from chrysanthemums
Feverfew = Tanacetum parthenium, called the “scourge of India”; wild feverfew can cause erythema multiforme
Alliaceae
Onions, garlic, chive
Mnemonic: “Allia” like aioli
Allergen = diallyl disulfide (a thiocyanate)
May also cause irritant dermatitis
Others
Buttercup
Allergen = ranunculin
Pineapple
Allergen = bromelain
Latex
Increased in atopic, spina bifida pts
Cross-reactants: mnemonic “Passion on your BACK” = passion fruit, banana, avocado, chestnuts, kiwiStay updated, free articles. Join our Telegram channel
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