Eczematous Diseases




(1)
Department of Dermatology, University of Pennsylvania, Penn Presbyterian Medical Center Medical Arts Building, Philadelphia, PA, USA

 




Abstract

Eczematous diseases are mostly epidermal. They are defined by “spongiotic dermatitis” on pathology, and clinically they may present in one of three stages (acute, subacute, or chronic) and in different contexts (types). The word “eczema” is derived from ancient Greek, meaning “to boil,” a reflection of the acute vesicular stage. Though many physicians and lay people use the word “eczema” synonymously with “atopic dermatitis,” the word “eczema” in this book is used differently. “Eczema” (or “dermatitis”) here is defined as a spongiotic reaction pattern that may present in different locations and contexts, with different names applied. For instance, in the context of atopy, a spongiotic dermatitis could be called atopic dermatitis. Other diseases including pityriasis rosea and dermatophytosis can also cause a spongiotic dermatitis.


Keywords
Eczematous diseasesEczema



3.1 The Three Stages of Eczema



3.1.1 Acute






  • Clinical = edematous, red, vesicular, weeping eruption


  • Ddx vesiculobullous disease


  • Path: stratum corneum = basket weave, epidermis = intraepidermal vesicles/spongiosis, dermis = mild infiltrate


3.1.2 Subacute






  • Clinical = red and scaly eruption, may have crusting


  • Ddx papulosquamous disease


  • Path: stratum corneum = scale/crust, epidermis = acanthosis, exocytosis, dermis = denser infiltrate


3.1.3 Chronic






  • Clinical = dry, lichenified eruption


  • Path: stratum corneum = hyper/parakeratosis, epidermis = less spongiosis/more psoriasiform, dermis = fibrosis


3.2 Types of Eczema






  • CANDID SCALES mnemonic1



    • Contact, Atopic, Nummular, Dyshidrotic, Id reaction and Infectious eczematoid, Drug, Stasis, CTCL, Asteatotic, LSC, Erythroderma, Seborrheic

Classic clues to distinguishing different eczematous disorders

Location



  • Legs – asteatotic eczema, stasis dermatitis


  • Hands/feet – dyshidrotic eczema, contact dermatitis


  • Ankles/neck – lichen simplex chronicus


  • Antecubital/popliteal fossae/face – atopic dermatitis


Pattern



  • Round weepy plaques – nummular eczema


  • Lichenified plaques – lichen simplex chronicus, atopic dermatitis


  • Linear or patterned mostly on hands/ft – contact dermatitis


  • Generalized – atopic dermatitis, cutaneous T-cell lymphoma, drug reaction


Associated Disease



  • Asthma/allergic rhinitis – atopic dermatitis


  • Venous stasis – stasis dermatitis


  • Wound – contact dermatitis (neomycin), infectious eczematoid


  • Lower extremity infection or dermatitis – id reaction


  • Psychiatric disorder or “neurodermatitis” – lichen simplex chronicus


3.2.1 Contact Dermatitis




(a)

Allergic contact dermatitis (ACD)

 

(b)

Irritant contact dermatitis (ICD)

 

(c)

Photoallergic contact dermatitis

 

(d)

Phototoxic contact dermatitis

 




  • Contact dermatitis can be divided by the type and specificity of the eruption. Irritant dermatitis causes 80 % of reactions, allergic only 20 %


3.2.1.1 Allergic Contact Dermatitis






  • An immunologic response in some individuals, type IV hypersensitivity reaction, 24–48 hours after contact (on re-exposure)


  • Clinical suspicion with patterned, linear, or geometric shapes; anatomical restriction to hands or feet, for instance. Eyelids are easily affected.


  • Patch testing may be indicated to detect allergen; most common test is TRUE test = Thin-layer Rapid Use Epicutaneous test


Common Contact Allergen Categories



  • Plants


  • Metals


  • Fragrances


  • Preservatives


  • Textiles


  • Personal care products


  • Topical medications


Plants



  • Four main genera of plants responsible for allergic contact dermatitis, all start with the letter A (Mnemonic AAAA):




  • Anacardiaceae


  • Alstroemeriaceae


  • Asteraceae


  • Alliaceae




  • Anacardiaceae (cashew and sumac family)



    • Toxicodendron is the poison ivy genera, formerly Rhus (reaction was called Rhus dermatitis)


    • Poison ivy (pointed 3 leaves)


    • Poison sumac (many pointed leaves)


    • Poison oak (rounded 3 leaves)


    • #1 plant cause of allergic contact dermatitis = poison ivy


    • Allergen = sap containing urushiol (a mixture of catechols)


    • Common cross reactants (all in Anacardiaceae family): cashew (Anacardium occidentale), mango rind (not fruit), gingko tree (leaf pulp, not supplement), lacquer tree of Japan, Brazilian pepper tree, Indian marking tree


    • Can cause erythema multiforme


    • Bentoquatam (IvyBlock) absorbs urushiol and can prevent eruption


    • Mnemonic: Anacardiaceae sounds like Ana Kardashian, the lesser known Kardashian that stings and burns


  • Alstroemeriaceae (Peruvian lily)



    • #1 cause of contact dermatitis in florists


    • Sensitizer = tuliposidase A


  • Asteraceae



    • Star-shaped plants (“aster” = star in Latin) = chrysanthemum (#2 cause of contact in florists), ragweed, feverfew, artichoke


    • Sensitizer = sesquiterpene lactones (SQLs)


    • Permethrin is made from chrysanthemums


    • Feverfew = Tanacetum parthenium, called the “scourge of India”; wild feverfew can cause erythema multiforme


  • Alliaceae



    • Onions, garlic, chive


    • Mnemonic: “Allia” like aioli


    • Allergen = diallyl disulfide (a thiocyanate)


    • May also cause irritant dermatitis


  • Others

Oct 6, 2016 | Posted by in Dermatology | Comments Off on Eczematous Diseases

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