Dupuytren Diathesis and Genetic Risk

Dolmans GH, de Bock GH, Werker PM (Univ Med Ctr Groningen and Univ of Groningen, the Netherlands) J Hand Surg 37A:2106-2111, 2012^§

Abstract

Purpose

Dupuytren disease (DD) is a benign fibrosing disorder of the hand and fingers. Recently, we identified 9 single nucleotide polymorphisms (SNPs) associated with DD in a genome-wide association study. These SNPs can be used to calculate a genetic risk score for DD. The aim of this study was to test whether certain clinical characteristics (including the DD diathesis features) of patients with DD are associated with a high genetic risk score.

Methods

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