Hand and Upper Extremity

Injectable Collagenase Clostridium Histolyticum for Dupuytren’s Contracture

Hurst LC, Badalamente MA, Hentz VR, et al (State Univ of New York; Stanford Hosps and Clinics, Palo Alto, CA; et al) N Engl J Med 361:968-979, 2009^§

D.J. Smith, Jr., MD

Evidence Ranking

• B

Expert Rating

• 3

Abstract

Background

Dupuytren’s disease limits hand function, diminishes the quality of life, and may ultimately disable the hand. Surgery followed by hand therapy is standard treatment, but it is associated with serious potential complications. Injection of collagenase clostridium histolyticum, an office-based, nonsurgical option, may reduce joint contractures caused by Dupuytren’s disease.