© Springer International Publishing Switzerland 2015
Robert A Norman and Reena RupaniClinical Cases in Integrative DermatologyClinical Cases in Dermatology410.1007/978-3-319-10244-3_1414. A 22-Year-Old Hispanic Woman Presented to the Office Asking for Evaluation of a Rash on Her Face
(1)
Dermatology Healthcare, Tampa, FL, USA
(2)
Lake Erie College of Osteopathic Medicine, Bradenton, FL, USA
Case Presentation
A 22-year-old Hispanic woman presented to the office asking for evaluation of a rash on her face. The patient complained that the rash appeared on her nose and cheeks after brief sun exposure and lasted for nearly a week. She stated that this has occurred on multiple occasions within this past year. Physical exam revealed a superficial erythematous plaque on the nasal bridge and cheekbones. The patient admitted that she was not diligent about applying sunscreen on her face in the past. She is not on any medications, and her family history is remarkable for rheumatoid arthritis in her mother and lupus in her maternal grandmother.
Differential Diagnosis
1.
Dermatomyositis
2.
Cutaneous lupus erythematosus
3.
Rosacea
4.
Seborrheic dermatitis
Diagnosis
Cutaneous lupus erythematosus
Discussion
Dermatomyositis is an inflammatory disease of the skin and skeletal muscles. Although the muscular inflammation can occur after the cutaneous manifestations in this disease, the patient did not present with the characteristic skin involvement of the hands and knuckles of dermatomyositis, making this diagnosis less likely. Rosacea often occurs after the age of 30 and often appears with papules and pustules. Although this patient’s lesion was located in an area common for rosacea, the diagnosis is less likely. Finally, seborrheic dermatitis can present as a red lesion over the malar region of the face; however, it may also present with dry, yellow scale at the inflamed base which this patient did not have.
Overview
Systemic lupus erythematosus (SLE) is a multisystem connective tissue disease affecting the blood, joints, skin, and kidneys. It primarily affects women in their 20s and 30s with a higher incidence in blacks and Hispanics. The severity of this disease is highly variable and may present with exacerbations and remissions throughout a patient’s life. Common symptoms include fatigue, fever, and arthralgia, and approximately 50 % of patients present with cutaneous features including a butterfly rash, discoid lupus, and photosensitivity [1–3].
Pathogenesis
The onset of SLE has been linked to genetics and the environment. Greater risk of developing SLE exists for patients whose family members have the disease. Environmental factors which exacerbate SLE or precipitate its onset include UV light exposure, infections, estrogen, medications, stress, surgery, and pregnancy. Such factors may lead to cell destruction and creation of antibodies against nuclear antigens. Further, an allele of STAT4, a transcription factor used in mediating responses to IL-12 in lymphocytes and in regulation of T helper cell differentiation, is associated with increased risk for SLE [1–3].
Clinical Presentation
Cutaneous lupus erythematosus can more commonly present as a rash, telangiectasia, alopecia, utricaria, or Raynaud’s phenomenon.

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