Peripheral Nerve Injury and Repair

Glatiramer Acetate Immune System Augmentation for Peripheral Nerve Regeneration in Rat Crushed Sciatic Nerve Model

Luria S, Waitayawinyu T, Conniff J, et al (Univ of Washington School of Medicine, Seattle) J Bone Joint Surg Am 92:396-403, 2010^§

Abstract

Background

Protective antiself response to nervous system injury has been reported to be mediated by a T-cell subpopulation that can recognize self-antigens. Immune cells have been shown to play a role in the regulation of motor neuron survival after a peripheral nerve injury. The objective of the present study was to evaluate the effects of immune system augmentation with use of the antigen glatiramer acetate, which is known to affect T-cell immunity, on peripheral nerve regeneration.

Methods

Wild-type and nude-type (T-cell-deficient) rats underwent crush injury of the sciatic nerve. Three and six weeks after the injury, the sciatic nerve was examined, both functionally (on the basis of footprint analysis and the tibialis anterior muscle response and weight) and histologically (on the basis of axon count).

Results

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