Neural Integration, Pain and Anesthesia

Changes in Tissue Substance P Levels in Patients With Carpal Tunnel Syndrome

Öztürk N, Erin N, Tüzüner S (Akdeniz Univ, Antalya, Turkey) Neurosurgery 67:1655-1661, 2010^§

Abstract

Background

Although carpal tunnel syndrome (CTS) is the most common entrapment neuropathy in adults, its etiology is not completely known. Chronic inflammation, fibrosis of the transverse carpal ligament (TCL), and altered sensory response contribute to the symptoms.

Objective

Because substance P (SP) is known to be involved in neuropathic pain, chronic inflammation, and fibrosis, the present study evaluated changes in SP levels in patients with CTS.

Methods

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